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Ca 2+ -Signal Transduction Inhibitors, Kujiol A and Kujigamberol B, Isolated from Kuji Amber Using a Mutant Yeast

2018; American Chemical Society; Volume: 81; Issue: 4 Linguagem: Inglês

10.1021/acs.jnatprod.7b00922

1520-6025

Takeshi Uchida, Hiroyuki Koshino, Shunya Takahashi, Eisaku Shimizu, Honoka Takahashi, Jun Yoshida, Hisao Shinden, Maiko Haga‐Tsujimura, Hisayoshi Kofujita, Shota Uesugi, Ken‐ichi Kimura,

Microbial Natural Products and Biosynthesis

A podocarpatriene and a labdatriene derivative, named kujiol A [13-methyl-8,11,13-podocarpatrien-19-ol (1)] and kujigamberol B [15,20-dinor-5,7,9-labdatrien-13-ol (2)], respectively, were isolated from Kuji amber through detection with the aid of their growth-restoring activity against a mutant yeast strain ( zds1Δ erg3Δ pdr1Δ pdr3Δ), which is known to be hypersensitive with respect to Ca2+-signal transduction. The structures were elucidated by spectroscopic data analysis. Compounds 1 and 2 are rare organic compounds from Late Cretaceous amber, and the mutant yeast used seems useful for elucidating a variety of new compounds from Kuji amber specimens, produced before the K-Pg boundary.