Cystic Renal Cell Carcinoma: A Report on Outcomes of Surgery and Active Surveillance in Patients Retrospectively Identified on Pretreatment Imaging
2018; Lippincott Williams & Wilkins; Volume: 200; Issue: 2 Linguagem: Inglês
10.1016/j.juro.2018.02.3087
ISSN1527-3792
AutoresMahyar Kashan, Mazyar Ghanaat, Andreas M. Hötker, Cihan Düzgöl, Alejandro Sánchez, Renzo G. DiNatale, Kyle A. Blum, Maria F. Becerra, Brandon J. Manley, Jozefina Casuscelli, Michael Chiok, Jonathan Coleman, Paul Russo, Satish K. Tickoo, Oğuz Akın, A. Ari Hakimi,
Tópico(s)Bladder and Urothelial Cancer Treatments
ResumoNo AccessJournal of UrologyAdult Urology1 Aug 2018Cystic Renal Cell Carcinoma: A Report on Outcomes of Surgery and Active Surveillance in Patients Retrospectively Identified on Pretreatment Imaging Mahyar Kashan, Mazyar Ghanaat, Andreas M. Hötker, Cihan Duzgol, Alejandro Sanchez, Renzo G. DiNatale, Kyle A. Blum, Maria F. Becerra, Brandon J. Manley, Jozefina Casuscelli, Michael Chiok, Jonathan A. Coleman, Paul Russo, Satish K. Tickoo, Oguz Akin, and A. Ari Hakimi Mahyar KashanMahyar Kashan Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Mazyar GhanaatMazyar Ghanaat Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Andreas M. HötkerAndreas M. Hötker Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York , Cihan DuzgolCihan Duzgol Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York , Alejandro SanchezAlejandro Sanchez Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Renzo G. DiNataleRenzo G. DiNatale Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Kyle A. BlumKyle A. Blum Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Maria F. BecerraMaria F. Becerra Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida , Brandon J. ManleyBrandon J. Manley Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Jozefina CasuscelliJozefina Casuscelli Department of Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York Department of Urology, Ludwig-Maximilians University, Munich, Germany , Michael ChiokMichael Chiok Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Jonathan A. ColemanJonathan A. Coleman Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Paul RussoPaul Russo Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York , Satish K. TickooSatish K. Tickoo Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York , Oguz AkinOguz Akin Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York , and A. Ari HakimiA. Ari Hakimi Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.3087AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the outcomes of surgical intervention and active surveillance in patients diagnosed with cystic renal cell carcinoma at our hypothesized radiological cutoff of greater than 50% cystic. Materials and Methods: We identified all 430 patients with a pathologically confirmed cystic renal mass that fit our criteria from 2000 to 2015. The 292 patients with a lack of computerized tomography, tumors less than 50% cystic on imaging, multifocal tumors and prior renal cell carcinoma were excluded from study. Patients were stratified into benign or malignant subgroups, and radiological, clinicopathological and oncologic features were determined. Univariate and multivariate associations between clinicoradiological parameters in each group were analyzed. We similarly reviewed the records of a separate cohort of patients treated with active surveillance for cystic renal cell carcinoma. Results: Of the 138 identified cases of cystic renal cell carcinoma 102 (73.9%) were renal cell carcinoma and 36 (26.1%) were benign masses. Of the tumors 77.5% were Fuhrman grade 1-2, 83.4% were stage pT2 or less and 65.9% showed clear cell histology. On univariate analysis male gender, a solid component and increasing Bosniak classification were significant for malignancy. In a separate cohort we identified 38 patients on active surveillance. The growth rate was 1.0 mm per year overall and 2.3 mm per year for the solid component. At a median followup of more than 4 years in all cohorts there was no evidence of recurrence or metastasis of cystic renal cell carcinoma. 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Link, Google Scholar © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byLee R, Uzzo R, Anaokar J, Thomas A, Wei S, Ristau B, McIntosh A, Lee M, Chen D, Greenberg R, Viterbo R, Smaldone M, Correa A, Schober J, Ginsburg K, Bukavina L, Magee D, Uzzo N, Parkansky P, Ruth K and Kutikov A (2023) Pathological and Clinical Outcomes in a Large Surveillance and Intervention Cohort of Radiographically Cystic Renal MassesJournal of Urology, VOL. 209, NO. 4, (686-693), Online publication date: 1-Apr-2023.Reese A (2018) Editorial CommentJournal of Urology, VOL. 200, NO. 6, (1198-1199), Online publication date: 1-Dec-2018.Smith J (2018) This Month in Adult UrologyJournal of Urology, VOL. 200, NO. 2, (215-217), Online publication date: 1-Aug-2018. Volume 200Issue 2August 2018Page: 275-282Supplementary Materials Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.Keywordsrenal cellcarcinomanephrectomycystskidneywatchful waitingMetricsAuthor Information Mahyar Kashan Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Mazyar Ghanaat Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Andreas M. Hötker Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Cihan Duzgol Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Alejandro Sanchez Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Renzo G. DiNatale Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Kyle A. Blum Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Maria F. Becerra Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida More articles by this author Brandon J. Manley Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Jozefina Casuscelli Department of Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York Department of Urology, Ludwig-Maximilians University, Munich, Germany More articles by this author Michael Chiok Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Jonathan A. Coleman Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Paul Russo Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Satish K. Tickoo Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Oguz Akin Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author A. Ari Hakimi Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York More articles by this author Expand All Advertisement PDF downloadLoading ...
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