Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
2018; Nature Portfolio; Volume: 9; Issue: 1 Linguagem: Inglês
10.1038/s41467-018-02942-5
ISSN2041-1723
AutoresAlison P. Klein, Brian M. Wolpin, Harvey A. Risch, Rachael Z. Stolzenberg‐Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J. Childs, Jason W. Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A. Arslan, Ana Babić, William R. Bamlet, Laura E. Beane Freeman, Sonja I. Berndt, Amanda L. Blackford, Michael Borges, Ayelet Borgida, Paige M. Bracci, Lauren K. Brais, Paul Brennan, Hermann Brenner, Bas Bueno‐de‐Mesquita, Julie E. Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G. Chaffee, Charles C. Chung, Sean P. Cleary, Michelle Cotterchio, Frederike Dijk, Eric J. Duell, Lenka Foretová, Charles S. Fuchs, Niccola Funel, Steven Gallinger, J. Michael Gaziano, Maria Gazouli, Graham G. Giles, Edward Giovannucci, Michael Goggins, Gary E. Goodman, Phyllis J. Goodman, Thilo Hackert, Christopher A. Haiman, Patricia Hartge, Manal Hasan, Péter Hegyi, Kathy J. Helzlsouer, Joseph M. Herman, Ivana Holcátová, Elizabeth A. Holly, Robert N. Hoover, Rayjean J. Hung, Eric J. Jacobs, Krzysztof Jamroziak, Vladimír Janout, Rudolf Kaaks, Kay‐Tee Khaw, Eric A. Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H. Kulke, Juozas Kupčinskas, Robert J. Kurtz, Daniel A. Laheru, Stefano Landi, Rita T. Lawlor, I.-Min Lee, Loı̈c Le Marchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Männistö, Roger L. Milne, Beatrice Mohelníková-Duchoňová, Rachel Ε. Neale, John P. Neoptolemos, Ann L. Oberg, Sara H. Olson, Irene Orlow, Claudio Pasquali, Alpa V. Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Ghislaine Scélo, Howard D. Sesso, Gianluca Severi, Xiao‐Ou Shu, Debra T. Silverman, Jill P. Smith, Pavel Souček, Malin Sund, Renata Talar‐Wojnarowska, Francesca Tavano, Mark Thornquist, Geoffrey S. Tobias, Stephen K. Van Den Eeden, Yogesh K. Vashist, Kala Visvanathan, Pavel Vodička, Jean Wactawski‐Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch‐Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen J. Chanock, Ofure Obazee, Gloria M. Petersen, Laufey T. Ámundadóttir,
Tópico(s)Cancer Genomics and Diagnostics
ResumoIn 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10
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