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Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

2018; Springer Science+Business Media; Volume: 48; Issue: 7 Linguagem: Inglês

10.1007/s10803-018-3510-4

1573-3432

Julian Tillmann, Karen L. Ashwood, Michael Absoud, Sven Bölte, Frédérique Bonnet‐Brilhault, Jan K. Buitelaar, Sara Calderoni, Rosa Calvo, Ricardo Canal‐Bedia, Roberto Canitano, Annelies de Bildt, Marie Gomot, Pieter J. Hoekstra, Anett Kaale, Helen McConachie, Declan Murphy, Antonio Narzisi, Iris J. Oosterling, Milica Pejović-Milovančević, Antonio M. Persico, Olga Puig, Herbert Roeyers, Nanda Rommelse, Roberto Sacco, Valeria Scandurra, Andrew C. Stanfield, Eric Zander, Tony Charman,

Genetics and Neurodevelopmental Disorders

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.