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Report of the Standardized Outcomes in Nephrology–Hemodialysis (SONG-HD) Consensus Workshop on Establishing a Core Outcome Measure for Hemodialysis Vascular Access

2018; Elsevier BV; Volume: 71; Issue: 5 Linguagem: Inglês

10.1053/j.ajkd.2017.12.003

1523-6838

Charmaine E. Lok, Allison Tong, Emma O’Lone, Angela Ju, Camilla S. Hanson, Bénédicte Sautenet, Jonathan C. Craig, Braden Manns, Martin Howell, Eric Chemla, Lai Seong Hooi, David W. Johnson, Timmy Lee, Charmaine E. Lok, Kevan R. Polkinghorne, Robert R. Quinn, Tushar J. Vachharajani, Raymond Vanholder, Li Zuo, Fergus Caskey, Adeera Levin, Allison Tong, Andrea Viecelli, Angela Ju, Angela Yee‐Moon Wang, Anna Porter, Benedicte Sautenent, Bharathi Reddy, Braden Manns, Brenda R. Hemmelgarn, Brigitte Schiller, Camilla S. Hanson, Carmel M. Hawley, Charmaine Lok, David C. Wheeler, David C.H. Harris, David W. Johnson, Dori Schatell, Eduardo Lacson, Elena Bavlovlenkov, Emma O’Lone, Eric Chemla, Fergus Caskey, Giovanni FM Strippoli, Harold I. Feldman, Ibironke W. Apata, Jan H.M. Tordoir, Jennifer E. Flythe, John Gill, John W. Kusek, Jonathan C. Craig, Kevan R. Polkinghorne, Kevin C. Abbott, Lai Seong Hooi, Laura M. Dember, Li Zuo, Lilia Cervantes, Louise Moist, Lynn Poole, Marcello Tonelli, Martin Howell, Maurizio Gallieni, Meghan J Elliot, Michael Klusmeyer, Michelle A. Josephson, Michelle L. Robbin, Miguel C. Riella, Nicole Evangelidis, Peter Tugwell, Peter G. Kerr, Pietro Ravani, Prabir Roy‐Chaudhury, Rajnish Mehrotra, Raymond Vanholder, Robert R. Quinn, Roberto Pécoits-Filho, Sally Crowe, Sharrilyn Evered, Stephan Segerer, Stephen Z. Fadem, Stephen P. McDonald, Stuart M. Sprague, Suetonia C. Palmer, Tammy Poma, Timmy Lee, Tushar J. Vachharajani, Vanja Sikirica, Vivekanand Jha, Wim Van Biesen, Wolfgang C. Winkelmayer­, Alison Mayers, Barry Bell, Jane Carter, Kimberly Hardy, Mary G. Ennis, M.P. Johnson, Noah Rouse, S.G. Wright, Tess Harris, U Khan Muhammad, Vanessa McNorton, David Mayers, David Ennis,

Health Systems, Economic Evaluations, Quality of Life

Vascular access outcomes in hemodialysis are critically important for patients and clinicians, but frequently are neither patient relevant nor measured consistently in randomized trials. A Standardized Outcomes in Nephrology-Hemodialysis (SONG-HD) consensus workshop was convened to discuss the development of a core outcome measure for vascular access. 13 patients/caregivers and 46 professionals (clinicians, policy makers, industry representatives, and researchers) attended. Participants advocated for vascular access function to be a core outcome based on the broad applicability of function regardless of access type, involvement of a multidisciplinary team in achieving a functioning access, and the impact of access function on quality of life, survival, and other access-related outcomes. A core outcome measure for vascular access required demonstrable feasibility for implementation across different clinical and trial settings. Participants advocated for a practical and flexible outcome measure with a simple actionable definition. Integrating patients' values and preferences was warranted to enhance the relevance of the measure. Proposed outcome measures for function included "uninterrupted use of the access without the need for interventions" and "ability to receive prescribed dialysis," but not "access blood flow," which was deemed too expensive and unreliable. These recommendations will inform the definition and implementation of a core outcome measure for vascular access function in hemodialysis trials.