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Pathogenesis of Proteus mirabilis Infection

2018; American Society for Microbiology; Volume: 8; Issue: 1 Linguagem: Inglês

10.1128/ecosalplus.esp-0009-2017

2324-6200

Chelsie E. Armbruster, Harry L. T. Mobley, Melanie M. Pearson,

Plant Pathogenic Bacteria Studies

, a Gram-negative rod-shaped bacterium most noted for its swarming motility and urease activity, frequently causes catheter-associated urinary tract infections (CAUTIs) that are often polymicrobial. These infections may be accompanied by urolithiasis, the development of bladder or kidney stones due to alkalinization of urine from urease-catalyzed urea hydrolysis. Adherence of the bacterium to epithelial and catheter surfaces is mediated by 17 different fimbriae, most notably MR/P fimbriae. Repressors of motility are often encoded by these fimbrial operons. Motility is mediated by flagella encoded on a single contiguous 54-kb chromosomal sequence. On agar plates,