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P156 Differential characteristics of patients with inflammatory bowel disease onset in paediatric age compared with patients diagnosed in adulthood: Results from the CAROUSEL study of GETECCU

2018; Oxford University Press; Volume: 12; Issue: supplement_1 Linguagem: Inglês

10.1093/ecco-jcc/jjx180.283

1876-4479

María Chaparro, A Garre, Elena Ricart, Valle García-Sánchez, Carlos Taxonera, Míriam Mañosa, Isabel Vera Mendoza, Miguel Mínguez, Federico Argüelles‐Arias, Luisa de Castro Parga, M Arroyo, Antonio López-San Román, Montserrat Rivero, Jordi Guardiola, María Dolores Martín‐Arranz, Belén Beltrán, Jesús Barrio, Sabino Riestra, Esther García-Planella, Xavier Calvet, G Alcaín, Beatriz Sicilia, Santiago García‐López, María Esteve, Lucía Márquez, Luís Fernández-Salazar, Ana Gutiérrez, Marta Piqueras, Iván Guerra, J L Pérez Calle, Joaquín Hinojosa, A Rodríguez, Xavier Aldeguer, M F García-Sepulcre, Luís Bujanda, P Martínez Montiel, R Llorente Poyatos, Cristina Rodríguez Gutiérrez, Olga Merino, José Luis Cabriada, Óscar Roncero, Patricia Romero Cara, Mercè Navarro-Llavat, Yolanda Ber, Rosa Eva Madrigal, Manuel Van Domselaar, Manuel Barreiro‐de Acosta, J Llaó, Laura Ramos, J Riera, Alfredo José Lucendo Villarín, Eugenia Rodriguez González, José María Huguet Malavés, Carmen Muñoz Villafranca, Pedro Almela, Mara Charro, Patricia Ramírez de la Piscina, Eva Sesé, A. Lacruz, Sam Khorrami, Víctor Jair Morales-Alvarado, Jerzy Gil, A. Martínez Martínez, Ramón Pajares, Juan Acevedo, Antonio García‐Herola, Luis Hernández, Eduardo Terreros Muñoz, Marinus Durán, M Menacho, Víctor Manuel Navas‐López, Mirta Retamero, Eugeni Domènech, Javier P. Gisbert,

Eosinophilic Esophagitis

Population-based studies comparing the characteristics of paediatric IBD with IBD diagnosed in the adulthood are scarce. The aims of this study were (i) To compare the characteristics of IBD in patients diagnosed during childhood (≤16 years) with those from patients diagnosed in adulthood; (ii) to compare the incidence rate of initiation of immunosuppressants, biologic agents and surgery between both groups; and (iii) to evaluate the impact of the age at diagnosis on the initiation of immunosuppressants, biological agents and surgery. IBD patients from the ENEIDA registry—a large prospectively maintained Spanish database promoted by the Spanish Working Group in Crohn’s and Colitis (GETECCU), were included. In order to minimise the heterogeneity in the management of IBD patients, the inclusion was limited to those diagnosed after 1998, when the fist biological agent was approved for IBD in Europe. Patients diagnosed at ≤16 years comprised the paediatric cohort (PC), and those diagnosed >16 years were the adult cohort (AC). The cumulative incidences of immunosuppressive therapy, biological therapy and surgery, were estimated using Kaplan–Meier curves, which were compared by the log-rank test. Cox-regression analysis was performed to identify potential predictive factors to receive immunosuppressants, biological agents or surgery. From 35925 patients, there were 1630 paediatric cases (4.5%) and from them, 56 (3.4%) were very-early-onset IBD (<6 years). Median follow-up was 91 months in the PC and 72 months in the AC. The proportion of Crohn’s disease (CD), ileocolonic involvement and inflammatory behaviour at diagnosis was higher in the PC (Table 1). In the multivariate analysis, after adjusting for gender, type of IBD, extra intestinal manifestations, family history and smoking habit, the PC was associated with higher risk of immunomodulator use (hazard ratio [HR] = 1.47, 95% confidence interval [95% CI] = 1.38–1.58) and higher probability of receiving biologic treatment (HR = 1.53, 95% CI = 1.42–1.66). However, paediatric IBD was not associated with higher risk of surgery (Table 2). Paediatric IBD has differential characteristics in comparison with adult IBD. In addition, paediatric IBD seems to be associated with higher use of immunosuppressant and biologics during follow-up. Nevertheless, paediatric IBD is not associated with higher risk of surgery.