Portal de Periódicos da CAPES

Nano-perovskite decorated carbon nanotubes composite for ultrasensitive determination of a cardio-stimulator drug

2018; Elsevier BV; Volume: 816; Linguagem: Inglês

10.1016/j.jelechem.2018.03.040

1873-2569

Ekram H. El‐Ads, Nada F. Atta, Ahmed Galal, Asmaa R.M. El-Gohary,

Pharmacological Effects and Assays

In this work, a new electrochemical sensor was fabricated based on Sr2PdO3 nano-perovskite manually mixed with carbon nanotubes (CNTs) and casted on glassy carbon (GC) electrode surface; GC/(CNTs-Sr2PdO3). Enhanced sensitivity, selectivity, stability and electron transfer kinetics were realized by the application of nano-perovskite modified carbon nanotubes composite for determination of dobutamine (DB). The proposed sensor showed high electro-catalytic activity in the linear dynamic range of 0.03 μmol L−1 to 50 μmol L−1 with sensitivity of 20.91 μA/μmol L−1, detection limit of 0.012 nmol L−1 and a quantification limit of 0.04 nmol L−1. The proposed method was successfully applied for DB detection in blood serum samples with good recovery results. The sensor showed anti-interfering ability in presence of common interferences as ascorbic acid, uric acid, acetaminophen, serotonin and morphine.