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Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

2018; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 3 Linguagem: Inglês

10.3390/v10030101

1999-4915

Jonas D. Albarnaz, Alice A. Torres, Geoffrey L. Smith,

Plant Virus Research Studies

The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of vaccinia virus (VACV) to enhance vaccine immunogenicity and safety. The virulence, immunogenicity and protective efficacy of VACV strains engineered to lack specific immunomodulatory or host range proteins are described. The ultimate goal is to develop safer and more immunogenic VACV vaccines that induce long-lasting immunological memory.