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Pyrazines from bacteria and ants: convergent chemistry within an ecological niche

2018; Nature Portfolio; Volume: 8; Issue: 1 Linguagem: Inglês

10.1038/s41598-018-20953-6

2045-2322

Eduardo A. Silva-Junior, Antonio C. Ruzzini, Camila Raquel Paludo, Fábio Santos do Nascimento, Cameron R. Currie, Jon Clardy, Mônica Tallarico Pupo,

Insect symbiosis and bacterial influences

Ants use pheromones to coordinate their communal activity. Volatile pyrazines, for instance, mediate food resource gathering and alarm behaviors in different ant species. Here we report that leaf-cutter ant-associated bacteria produce a family of pyrazines that includes members previously identified as ant trail and alarm pheromones. We found that L-threonine induces the bacterial production of the trail pheromone pyrazines, which are common for the host leaf-cutter ants. Isotope feeding experiments revealed that L-threonine along with sodium acetate were the biosynthetic precursors of these natural products and a biosynthetic pathway was proposed.