Portal de Periódicos da CAPES

Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance

2018; Taylor & Francis; Volume: 125; Issue: 1 Linguagem: Inglês

10.1080/13813455.2018.1437749

1744-4160

Mohammad Dallak, Ismaeel Bin‐Jaliah, Hussein F. Sakr, Bahjat Al‐Ani, Mohamed A. Haidara,

Lipid metabolism and disorders

We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis.Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-'treated' rats started swim exercise training from the 11th week until being sacrificed, on Week 15.HCFD caused a significant increase in blood glucose, insulin resistance (HOMA-IR), lipidemia, and inflammatory biomarkers. In addition, HCFD significantly modulated coagulation and thrombosis biomarkers; fibrinogen, plasminogen activator inhibitor-1, von Willebrand factor, prothrombin time, activated partial thromboplastin time, blood clotting and bleeding time, and ADP-induced platelet aggregation that was effectively inhibited by swimming exercises.We demonstrate that in an animal model of obesity and insulin resistance, there is a significant change in hemostasis, which is ameliorated by swim exercise.