A Highly Chemoselective Synthesis of Cyclic Divalent Propargylamines by Copper‐Catalyzed Annulation/Double A 3 ‐Couplings
2018; Wiley; Volume: 2018; Issue: 17 Linguagem: Inglês
10.1002/ejoc.201800393
ISSN1434-193X
AutoresYazhen Zhang, Huangdi Feng, Xiaohui Liu, Liliang Huang,
Tópico(s)Click Chemistry and Applications
ResumoDivalent propargylamines are prominent intermediates in the preparation of multidentate ligands, which have wide implications for use in catalysis. Herein, a highly chemoselective and versatile protocol for the construction of cyclic divalent propargylamines has been achieved under microwave irradiation. This sequential transformation comprises a copper‐catalyzed annulation/A 3 ‐coupling/A 3 ‐coupling of a primary diamine with formaldehyde solution and two alkynes to directly providing a diverse set of N , N′ ‐dipropargylimidazolidines and hexahydropyrimidines in moderate to excellent yields.
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