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Leprosy: current situation, clinical and laboratory aspects, treatment history and perspective of the uniform multidrug therapy for all patients

2017; Elsevier BV; Volume: 92; Issue: 6 Linguagem: Inglês

10.1590/abd1806-4841.20176724

1806-4841

Rossilene Conceição da Silva Cruz, Samira Bührer-Sékula, Maria Lúcia Fernandes Penna, Gerson Oliveira Penna, Sinésio Talhari,

Mycobacterium research and diagnosis

In this review, the most relevant and current epidemiological data, the main clinical, laboratory and therapeutical aspects of leprosy are presented. Detailed discussion of the main drugs used for leprosy treatment, their most relevant adverse effects, evolution of the therapeutic regimen, from dapsone as a monotherapy to the proposed polychemotherapy by World Health Organization (WHO) can be found in this CME. We specifically highlight the drug acceptability, reduction in treatment duration and the most recent proposal of a single therapeutic regimen, with a fixed six months duration, for all clinical presentations, regardless of their classification.