Produção Nacional
Revisado por pares
Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27
2018; Multidisciplinary Digital Publishing Institute; Volume: 23; Issue: 2 Linguagem: Inglês
10.3390/molecules23020279
ISSN1433-1373
AutoresGabriel Silva, Felipe Teixeira Lima, Viviane Seba, Ana Mendes Lourenço, Thaise Lucas, Bianca De Andrade, Guilherme Silva Torrezan, Carlos Roberto Polaquini, Carlos M. García, Lucélio Bernardes Couto, Reinaldo B. Bestetti, Suzelei de Castro França, Ana Lúcia Fachin, Luís Octávio Regasini, Mozart Marins,
Tópico(s)Protease and Inhibitor Mechanisms
ResumoGastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.
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