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ABSORBANCE RATIO METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF TENELIGLIPTIN HYDROBROMIDE HYDRATE (TENE) AND METFORMIN HYDROCHLORIDE (MET) IN TABLET DOSAGE FORM

2018; Volume: 9; Issue: 1 Linguagem: Inglês

10.7897/2230-8407.0917

ISSN

2230-8407

Autores

Hardi Joshi, Avani Khristi,

Tópico(s)

Spectroscopy and Chemometric Analyses

Resumo

A precise, accurate UV spectroscopic method was developed and validated for simultaneous estimation of Teneligliptin hydrobromide hydrate (TENE) and Metformin hydrochloride (MET HCl) in pharmaceutical dosage form.Wavelength selected for estimation were 233 nm and 249.20 nm in absorbance ratio method for TENE and MET HCl.Linearity of developed method was found to be 6-16µg/mL for TENE and MET HCl as the r 2 value was found to be near 1.Accuracy was found to be 98.33% -101.11% in absorbance ratio method for TENE and MET HCl.The Method validated as per ICH guidelines.

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