Portal de Periódicos da CAPES

Pharmacoepigenetics in Childhood Acute Lymphoblastic leukemia: Involvement of miRNA Polymorphisms in Hepatotoxicity

2018; Future Medicine; Volume: 10; Issue: 4 Linguagem: Inglês

10.2217/epi-2017-0138

1750-1911

Ángela Gutiérrez-Camino, Maitane Umerez, Borja Santos, Idoia Martín‐Guerrero, Nagore García de Andoín, Ana Méndez‐Echevarría, Aurora Navajas, Itziar Astigarraga, África García‐Orad,

MicroRNA in disease regulation

Aim: Hepatotoxicity is one of the most common drug-related toxicities during the treatment of childhood acute lymphoblastic leukemia (ALL). Many genes involved in liver-specific signaling pathways are tightly controlled by miRNAs, and miRNA function could be modulated by SNPs. As a consequence, we hypothesized that variants in miRNAs could be associated with drug-induced hepatotoxicity. Methods: We analyzed 213 SNPs in 206 miRNAs in a cohort of 179 children with ALL homogeneously treated. Results: rs2648841 in miR-1208 was the most significant SNP during consolidation phase after false discovery rate correction, probably through an effect on its target genes DHFR, MTR and MTHFR. Conclusion: These results point out the possible involvement of SNPs in miRNAs in toxicity to chemotherapy in children with ALL.