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Autoimmune postural orthostatic tachycardia syndrome

2018; Wiley; Volume: 5; Issue: 4 Linguagem: Inglês

10.1002/acn3.524

2328-9503

Mari Watari, Shunya Nakane, Akihiro Mukaino, Makoto Nakajima, Yukiko Mori, Yasuhiro Maeda, Teruaki Masuda, Koutaro Takamatsu, Yanosuke Kouzaki, Osamu Higuchi, Hidenori Matsuo, Yukio Ando,

Neurology and Historical Studies

Abstract The aim of this study was to evaluate the association between postural orthostatic tachycardia syndrome ( POTS ) and circulating antiganglionic acetylcholine receptor ( gAChR ) antibodies. We reviewed clinical assessments of Japanese patients with POTS , and determined the presence of gAChR antibodies in serum samples from those patients. Luciferase immunoprecipitation systems detected anti‐ gAChR α 3 and β 4 antibodies in the sera from POTS (29%). Antecedent infections were frequently reported in patients in POTS patients. Moreover, autoimmune markers and comorbid autoimmune diseases were also frequent in seropositive POTS patients. Anti‐ gAChR antibodies were detectable in significant number of patients with POTS , and POTS entailed the element of autoimmune basis.