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Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine

2018; Elsevier BV; Volume: 36; Issue: 12 Linguagem: Inglês

10.1016/j.vaccine.2018.02.027

1873-2518

Anastasiia L. Sycheva, Mikhail V. Pogorelyy, Ekaterina A. Komech, Anastasia A. Minervina, Ivan V. Zvyagin, Dmitriy B. Staroverov, Dmitriy M. Chudakov, Yuri B. Lebedev, Ilgar Z. Mamedov,

T-cell and B-cell Immunology

Vaccination against influenza is widely used to protect against seasonal flu epidemic although its effectiveness is debated. Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination.