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BIBTEX RIS

Role of TRPV 1 receptor in inflammation and impairment of esophageal mucosal integrity in a murine model of nonerosive reflux disease

2018; Wiley; Volume: 30; Issue: 8 Linguagem: Inglês

10.1111/nmo.13340

1365-2982

Renan O. Silva, Rudy Diavila Bingana, Thiago M. Sales, Rhubens Levy R. Moreira, Deiziane Viana da Silva Costa, Kamila Maria Oliveira Sales, Gerly Anne de Castro Brito, Armênio Aguiar dos Santos, M.A.N. Souza, Pedro Marcos Gomes Soares, Daniel Sifrim, Marcellus Henrique Loiola Ponte de Souza,

Eosinophilic Esophagitis

Microscopic inflammation and impairment of the esophageal epithelial barrier are considered relevant for perception of symptoms in patients with nonerosive reflux disease (NERD). In these patients, the receptor transient receptor potential vanilloid 1 (TRPV1) is overexpressed in the esophageal mucosa, but its role is not yet fully understood. We evaluated the role of TRPV1 in esophageal inflammation and mucosal barrier impairment in a murine model of NERD.