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Effect Of Metformin Alone Compared With Metformin Plus Simvastatin on Polycystic Ovarian Syndrome In Pakistani Women

2018; Volume: 28; Issue: 3 Linguagem: Inglês

10.29271/jcpsp.2018.03.184

1681-7168

Misbah Malik, Nasira Tasnim, Ghazala Mahmud,

Reproductive Biology and Fertility

To determine the efficacy of metformin alone versus metformin plus simvastatin for treatment of polycystic ovariansyndrome (PCOS).Randomized controlled trial.Maternal and Child Health Centre, Unit II, Pakistan Institute of Medical Sciences (PIMS), from November 2014 to April 2015.One hundred and eight patients (108) were randomly divided into metformin group (n=54) and metformin plus simvastatin group (n=54), detailed clinical history, including menstrual details, was taken with thorough examination performed. Baseline ultrasound was performed to evaluate ovarian size and these were considered enlarged with volume >10cc or with >12 follicles in any one ovary. Blood samples were taken at baseline and after three months of therapy to determine the LH/FSH ratio and lipid profile. Efficacy was defined as >15% decrease in the baseline values.The mean age of patients was 28.82 ±7.18 years. Mean BMI of the patients was 22.41 ±1.55 Kg/m2. Efficacy was achieved in 66.7% patients with metformin alone, while in 92.6% with combination medication (p=0.001).The combination of metformin plus simvastatin is more efficacious as compared to metformin alone for management of females with PCOS.