Protective effect of dietary fiber from sweet potato ( Ipomoea batatas L.) against lead-induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways
2018; Wiley; Volume: 42; Issue: 3 Linguagem: Inglês
10.1111/jfbc.12513
ISSN1745-4514
AutoresYi Zhang, Wenlong Gu, Liqin Duan, Hong Zhu, Hongyun Wang, Jing Wang, Jian Sun, Fuxiang Niu,
Tópico(s)Mesenchymal stem cell research
ResumoJournal of Food BiochemistryVolume 42, Issue 3 e12513 FULL ARTICLE Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead-induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways Yi Zhang, Yi Zhang Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorWenLong Gu, WenLong Gu Xuzhou Agricultural Products Quality Inspection Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorLiQin Duan, LiQin Duan Xuzhou Agricultural Products Quality Inspection Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorHong Zhu, Hong Zhu Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorHongYun Wang, HongYun Wang Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorJing Wang, Jing Wang Xuzhou Agricultural Products Quality Inspection Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorJian Sun, Corresponding Author Jian Sun xzsunjian@jaas.ac.cn Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaCorrespondence Jian Sun and FuXiang Niu, Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Room 8321, Research Building, Kunpeng Road, Xuzhou, 221131 Jiangsu Province, China. Emails: xzsunjian@jaas.ac.cn; niufuxiang@sina.comSearch for more papers by this authorFuXiang Niu, Corresponding Author FuXiang Niu niufuxiang@sina.com orcid.org/0000-0002-0381-374X Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaCorrespondence Jian Sun and FuXiang Niu, Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Room 8321, Research Building, Kunpeng Road, Xuzhou, 221131 Jiangsu Province, China. Emails: xzsunjian@jaas.ac.cn; niufuxiang@sina.comSearch for more papers by this author Yi Zhang, Yi Zhang Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorWenLong Gu, WenLong Gu Xuzhou Agricultural Products Quality Inspection Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorLiQin Duan, LiQin Duan Xuzhou Agricultural Products Quality Inspection Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorHong Zhu, Hong Zhu Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorHongYun Wang, HongYun Wang Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorJing Wang, Jing Wang Xuzhou Agricultural Products Quality Inspection Center, Xuzhou, Jiangsu Province, ChinaSearch for more papers by this authorJian Sun, Corresponding Author Jian Sun xzsunjian@jaas.ac.cn Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaCorrespondence Jian Sun and FuXiang Niu, Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Room 8321, Research Building, Kunpeng Road, Xuzhou, 221131 Jiangsu Province, China. Emails: xzsunjian@jaas.ac.cn; niufuxiang@sina.comSearch for more papers by this authorFuXiang Niu, Corresponding Author FuXiang Niu niufuxiang@sina.com orcid.org/0000-0002-0381-374X Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Xuzhou, Jiangsu Province, ChinaCorrespondence Jian Sun and FuXiang Niu, Sweet Potato Research Institute, CAAS/Jiangsu Xuzhou Sweet Potato Research Center, Room 8321, Research Building, Kunpeng Road, Xuzhou, 221131 Jiangsu Province, China. Emails: xzsunjian@jaas.ac.cn; niufuxiang@sina.comSearch for more papers by this author First published: 13 February 2018 https://doi.org/10.1111/jfbc.12513Citations: 3 Funding information: Jiangsu Self-Innovation Fund for Agricultural Science and Technology, Grant/Award Number: CX [14] 5090; China Agriculture Research System, Grant/Award Number: CARS-10-B20 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Dietary fiber (DF) is the main component of sweet potato residue, which has a variety of health benefits. However, the preventive effect of DF from sweet potato on lead (Pb)-induced renal injury remains unclear. This study identified the proximate composition and chemical components of DF extracted by ultrasound-assisted enzymatic hydrolysis. The administration of ordinary dietary fiber (ODF) and high-soluble dietary fiber (HSDF) decreased the blood and kidney Pb concentrations of Pb-exposed mice. Moreover, profound Pb-induced elevations of reactive oxygen species, malondialdehyde level, and depletion of intracellular glutathione level in kidney were suppressed by treatment with HSDF. Compared to the ODF group, HSDF activated AMP-activated protein kinase (AMPK)/silent information regulator T1 (SIRT1)/peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α) signaling in kidney, which directly regulates superoxide dismutase (SOD) and nuclear respiratory factors (NRF1)/mitochondrial transcription factor A (TFAM). In conclusion, HSDF supplementation ameliorates Pb-induced renal injury by inhibiting oxidative stress. Practical applications In China, sweet potato residue is discarded as waste, which causes environmental pollution. Sweet potato residue can be a cheap and widely available resource of DF, which was extracted by ultrasound-assisted enzymatic hydrolysis. This study provides biological evidence that supports the use of DF from sweet potato to prevent Pb accumulation and protect the kidney, thereby indicating that DF has a great potential to be used as natural Pb-excreting agent and functional ingredient in food products. CONFLICT OF INTEREST The authors declare no conflict of interest. Citing Literature Volume42, Issue3June 2018e12513 RelatedInformation
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