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Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients

2018; Elsevier BV; Volume: 13; Linguagem: Inglês

10.1016/j.inat.2018.02.001

2214-7519

S. Vysotski, Casey Madura, Benjamin Swan, Ryan Holdsworth, Yupei Lin, Alejandro Muñoz del Río, Janine Wood, Bornali Kundu, Amy Penwarden, Jed Voss, Tom Gallagher, Veena A. Nair, Aaron S. Field, Camille Garcia‐Ramos, M. Elizabeth Meyerand, Mustafa K. Başkaya, Vivek Prabhakaran, John S. Kuo,

Brain Metastases and Treatment

Functional Magnetic Resonance Imaging (fMRI) is a presurgical planning technique used to localize functional cortex so as to maximize resection of diseased tissue and avoid viable tissue. In this retrospective study, we examined differences in morbidity and mortality of brain tumor patients who received preoperative fMRI in comparison to those who did not.Brain tumor patients (n=206) were selected from a retrospective review of neurosurgical case logs from 2001-2009 at the University of Wisconsin-Madison.Univariate analysis showed improved mortality in the fMRI group and the fMRI+Electrical Cortical Stimulation Mapping (ECM) group compared to the No-fMRI group. Multivariate analyses showed improved mortality of the fMRI group and the fMRI+ECM group compared to the No-fMRI group, with age and tumor grade being the most significant influencers. Overall, the fMRI group showed survival benefits at 3 years; twice that of the No-fMRI group. Furthermore, patients with high-grade tumors showed significant survival benefits in the fMRI group, while patients with low-grade tumors did not (controlling for age and ECM). There was also a significant difference in the two groups with respect to morbidity, with patients receiving fMRI showing improved outcomes in the motor and language domains.This study analyzing a large retrospective series of brain tumor patients with and without the use of fMRI in the preoperative planning has resulted in improved mortality and morbidity outcomes with the use of fMRI. These results point to the importance of incorporating fMRI in presurgical planning in the clinical management of patients with brain tumors.