Produção Nacional
Revisado por pares
Immune-mediated Pericarditis With Pericardial Tamponade During Nivolumab Therapy
2018; Lippincott Williams & Wilkins; Volume: 41; Issue: 7 Linguagem: Inglês
10.1097/cji.0000000000000217
ISSN1537-4513
AutoresDaniel Vargas Pivato de Almeida, Jéssica Ribeiro Gomes, Fábio J. Haddad, Antônio C. Buzaid,
Tópico(s)Silicon Carbide Semiconductor Technologies
ResumoA 69-year-old man with metastatic lung adenocarcinoma presented with pericarditis and pericardial tamponade during nivolumab treatment, despite near-complete response on images performed during response evaluation. Further investigation found no evidence of pericardial or pleural cancer involvement, and pathologic evaluation showed immune-related adverse effect. Surgical and steroid treatments were used, with excellent results, and no disease progression on follow-up despite drug discontinuation because of toxicity. Although life-threatening immune-related adverse effects are not frequent when using checkpoint inhibitors, and cardiotoxicity is very rare, different clinical manifestations may occur, and some of them can be fatal in case of inadequate management. It may be challenging to make an etiological diagnosis; however, favorable outcomes can be achieved when prompt directed treatment is promoted.
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