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BIBTEX RIS

A comprehensive review of chalcone derivatives as antileishmanial agents

2018; Elsevier BV; Volume: 150; Linguagem: Inglês

10.1016/j.ejmech.2018.03.047

1768-3254

Marcos V. Palmeira‐Mello, Bárbara Abrahim-Vieira, Thaisa Francielle Souza Domingos, Jéssica B. de Jesus, Ana Carolina Corrêa de Sousa, Carlos Rangel Rodrigues, Alessandra Mendonça Teles de Souza,

Synthesis and biological activity

Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20 pathogenic species of Leishmania sp. Due to the limitations of the current treatments available, chalcone moiety has been drawn with a lot of attention due to the simple chemistry and synthesis, being reported with antileishmanial activity in particular against amastigote form. This review aims to provide an overview towards antileishmanial activity of chalcones derivatives against amastigote form for Leishmania major, L. amazonensis, L. panamensis, L. donovani and L. infantum as well as their structure-activity relationship (SAR), molecular targets and in silico ADMET evaluation. In this way, it is expected that this review may support the research and development of new promising chalcones candidates a leishmanicidal drugs.