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The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998–2012

2018; Elsevier BV; Volume: 94; Linguagem: Inglês

10.1016/j.ejca.2018.01.083

1879-0852

Luigino Dal Maso, Chiara Panato, Silvia Franceschi, Diego Serraino, Carlotta Buzzoni, S. Busco, Stefano Ferretti, Antonietta Torrisi, Fabio Falcini, Manuel Zorzi, Claudia Cirilli, Walter Mazzucco, Michele Magoni, Paolo Collarile, Fabio Pannozzo, Anna Luisa Caiazzo, Antonio Russo, Alessio Gili, Adele Caldarella, Roberto Zanetti, Maria Michiara, Lucìa Mangone, Rosangela Filiberti, Mario Fusco, Francesca Gasparini, Giovanna Tagliabue, Rosaria Cesaraccio, ­Rosario ­Tumino, Luciana V. Gatti, F. Tisano, Silvano Piffer, Giovanna Sini, Guido Mazzoleni, Stefano Rosso, Anna Clara Fanetti, Salvatore Vaccarella, Ugo Fedeli, Massimo Varvarà, Alessandra Ravaioli, Gianmaria Pennelli, K Valla, Rosanna Cusimano, Cinzia Gasparotti, Martina Taborelli, Arturo Iannelli, Sílvia Leite, Gianfranco Manneschi, S Patriarca, Paolo Sgargi, Massimo Vicentini, Antonella Puppo, Maria Francesca Vitale, Giulio Barigelletti, D Pirino, Eugenia Spata, Paolo Ricci, A Madeddu, Roberto Vito Rizzello, M. Usala, A. Bulatko, P Vercellino, I Cometti, Francesco Cuccaro, Giuseppe Sampietro, Santo Scalzi, G Gola, Linda Guarda, Anna Melcarne, Luca Cavalieri d’Oro, Elisabetta Borciani, Simona Carone, Giuseppina Candela, Giorgia Stoppa,

BRCA gene mutations in cancer

Aims In Italy, incidence rates of thyroid cancer (TC) are among the highest worldwide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attributable to overdiagnosis. Methods Data on TC cases reported to Italian cancer registries during 1998–2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results In Italy between 1998–2002 and 2008–2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (+91% in women, +120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998–2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008–2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders. Conclusion(s) Incidence rates of TC are steadily increasing in Italy and largely due to overdiagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.