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Importance of Site of Infection and Antibiotic Selection in the Treatment of Carbapenem-Resistant Pseudomonas aeruginosa Sepsis

2018; American Society for Microbiology; Volume: 62; Issue: 4 Linguagem: Inglês

10.1128/aac.02400-17

1098-6596

Nicholas Britt, David J. Ritchie, Marin H. Kollef, Carey‐Ann D. Burnham, Michael J. Durkin, Nicholas Hampton, Scott T. Micek,

Antibiotic Use and Resistance

In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39; P = 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90; P = 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85; P = 0.037), consistent across multiple sites of infection.