Portal de Periódicos da CAPES

Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery

2018; Wiley; Volume: 2; Issue: 3 Linguagem: Inglês

10.1002/adbi.201700123

2366-7478

Miranda So, Neel A. Mansukhani, Erica B. Peters, Mazen Albaghdadi, Zheng Wang, Charles M. Rubert Pérez, Melina R. Kibbe, Samuel I. Stupp,

RNA Interference and Gene Delivery

Co-assembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein-mimetic peptide, localize at plaque sites in LDL receptor knockout mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, non-targeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein-mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis.