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Protective Effect of Maternal Influenza Vaccination on Influenza in Their Infants: A Prospective Cohort Study

2017; Oxford University Press; Volume: 217; Issue: 6 Linguagem: Inglês

10.1093/infdis/jix629

1537-6613

Satoko Ohfuji, Masaaki Deguchi, Daisuke Tachibana, Masayasu Koyama, Toshiyuki Takagi, Takayuki Yoshioka, Akinori Urae, Kazuya Ito, Tetsuo Kase, Akiko Maeda, Kyoko Kondo, Wakaba Fukushima, Yoshio Hirota, Shiro Imai, E Akagaki, Mariko Akai, Y. Azuma, Shinichi Hamada, Satoru Motoyama, Hiroko Chimori, Shoko Nakagawa, Takehiko Fukuda, Masahisa Hagiwara, H. Okuda, Takuro Hamanaka, Seiichi Yamamasu, Kenji Hirota, Masataka Oku, Keizo Hiramatsu, Masanori Hisamatsu, Yasushi Iijima, Mikio Takehara, Somei Ikeda, Takeshi Inoue, Eriko Yamashita, Aisaku Fukuda, I. Iwata, Junko Nishio, Tateki Tsutsui, Kenji Yamaji, Takao Kamiya, Atsushi Kasamatsu, Tatsuya Nakajima, K Kasahara, Kenjitsu Kasamatsu, Kawabata Ryoichi, Kazume Kawabata, Kozo Kadowaki, Hiroshi Nomura, Tomoyuki Kikuchi, Ayako Suzuki, Tadayoshi Nagano, Yoshitsugu Komeda, R. Kondo, Shinjin Konishi, Hideo Takemura, Masako Kasumi, Kazuo Masuhiro, Ryoji Ito, Yoshiki Sakamoto, Kouzo Hirai, Yoshimitsu Yamamoto, Yoshitaka Kariya, O. Misaki, Akira Miyake, Yasuko Osako, Masao Mori, Keizo Naka, Y Tokura, Jun Yoshimatsu, Keiji Tatsumi, Takayoshi Kanda, Masahiro Nishikawa, Sekio Nishimoto, Yoshihiro Nishioka, Takao Funato, Kouichi Nozaki, Gengo Ohira, Yoshiyuki Okamura, Yuzo Oga, Osamu Nakamoto, Shinichi Nakata, Tetsuo Nakamura, Masahiko Takemura, Toshiyuki Sadou, Nobuaki Mitsuda, Daisuke Fujita, Koji Hisamoto, Shinobu Akada, Takafumi Nonogaki, Chinami Horiuchi, Yasuhiko Shiki, Tadashi Kimura, K. Kitamura, Kazuhide Ogita, Shigeki Matsuo, Yoshihito Ikeda, Akihiro Moriyama, Yukiyoshi Ishikawa, Hiroshi Muso, Fuminori Kitada, Toshiya Yamamoto, Megumi Takemura, Takeshi Sawada, Kentaro Shimura, K. Shinyashiki, Mitsuhiko Masuda, Tsuneo Shoda, Takamichi Nishizaki, Yoshinori Suzuki, Isao Suzuki, Hiroshi Nanjyo, K. Takabatake, Kikuya Takase, Satoshi Nakago, Jun Takeyama, Takeshi Taniguchi, Keiichi Tasaka, Toshiaki Tatsumi, Atsushi Tokuhira, Shogo Tsubokura, Kayoko Ueda, Yukiko Uenae, T Unno, Hiroshi Yabuki, Tokihiro Yanamoto, Yoshihiko Yamada, Nobuyuki Maruo, Yoshitsugu Takada,

Neuroscience of respiration and sleep

Infants <6 months of age are too young to receive influenza vaccine, despite being at high risk for severe influenza-related complications.To examine the effectiveness of maternal influenza vaccination in preventing influenza in their infants, we conducted a prospective cohort study of 3441 infants born at participating hospitals before the 2013-2014 influenza season. At the time of recruitment, their mothers completed a questionnaire about influenza vaccination status for the 2013-2014 season. A follow-up survey was conducted after the end of the 2013-2014 season to collect information regarding influenza diagnosis and hospitalization among infants.During the 2013-2014 influenza season, 71 infants (2%) had influenza diagnosed, and 13 infants (0.4%) were hospitalized with influenza. Maternal influenza vaccination (especially prenatal vaccination) decreased the odds of influenza among infants. The effectiveness of prenatal vaccination was 61% (95% confidence interval, 16%-81%), whereas that of postpartum vaccination was 53% (-28%-83%). Although maternal influenza vaccination was also associated with a decreased odds of influenza-related hospitalization among infants, vaccine effectiveness (73%) did not reach statistical significance, owing to the limited number of infants hospitalized because of influenza.The present findings indicated that pregnant women and postpartum women should receive influenza vaccination to protect their infants.