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Prospective associations between white matter hyperintensities and lower extremity function

2018; Lippincott Williams & Wilkins; Volume: 90; Issue: 15 Linguagem: Inglês

10.1212/wnl.0000000000005289

1526-632X

So Young Moon, Philipe de Souto Barreto, Yves Rolland, Marie Chupin, Ali Bouyahia, Ludovic Fillon, Jean François Mangin, Sandrine Andrieu, Matteo Cesari, Bruno Vellas, Bruno Vellas, Sophie Guyonnet, Isabelle Carrié, Sandrine Andrieu, Jean‐François Dartigues, Marie-Noëlle Cuffi, Lawrence Bories, Françoise Desclaux, Prof Thierry Dantoine, Kristelle Sudres, Jacques Touchon, Prof Philippe Robert, Yves Gasnier, Serge Bordes, Pierre Payoux, Julien Delrieu, Michèle Allard, Michel Zanca, Jacques Monteil, Jacques Darcourt, Christian Vincent, Lauréane Brigitte, Christelle Cantet, Christophe Morin, Sandrine Andrieu, Stéphanie Savy, Christelle Cantet, Nicola Coley,

Nutrition and Health in Aging

To evaluate the relationship of white matter hyperintensities (WMH) with decline in lower extremity function (LEF) over approximately 3 years in dementia-free older adults with memory complaints.We obtained brain MRI data from 458 community-dwelling adults, aged 70 years or over, at baseline, and from 358 adults over an average follow-up of 963 days. We evaluated LEF using the Short Physical Performance Battery (SPPB). We related baseline WMH volumes and progression to SPPB scores over time, using mixed-effect linear regressions. For the secondary analyses, we categorized baseline WMH volume into quartiles, and dichotomized the WMH progression to compare fast and slow progression.Baseline WMH volume (β = -0.017, 95% confidence interval [CI] -0.025 to -0.009), as well as WMH progression (β = -0.002, 95% CI -0.003 to -0.001), significantly associated with a decline in SPPB performance in adjusted analyses. Compared with the lowest quartile of baseline WMH volume, the highest quartile associated with a decline in SPPB performance (β = -0.301, 95% CI -0.558 to -0.044). Fast progression also associated with a decline in SPPB performance. We found clinically meaningful differences in the SPPB, with higher scores in participants with slow progression of WMH, at both 24 and 36 months.Baseline level and WMH progression associated with longitudinal decline in SPPB performance among older adults. We detected clinically meaningful differences in SPPB performance on comparing fast with slow progression of WMH, suggesting that speed of WMH progression is an important determinant of LEF during aging.