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Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data

2018; Wiley; Volume: 70; Issue: 5 Linguagem: Inglês

10.1002/art.40428

2326-5205

Dana E. Orange, Phaedra Agius, Edward F. DiCarlo, Nicolas Robine, Heather Geiger, Jackie Szymonifka, Michael McNamara, Ryan Cummings, Kathleen M. Andersen, Serene Z. Mirza, Mark P. Figgie, Lionel B. Ivashkiv, Alessandra B. Pernis, Caroline S. Jiang, Mayu O. Frank, Robert B. Darnell, Nithya Lingampali, William H. Robinson, Ellen M. Gravallese, Vivian P. Bykerk, Susan M. Goodman, Laura T. Donlin,

Systemic Lupus Erythematosus Research

In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA) synovial tissue by training with gene expression data and machine learning.