Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

2018; Nature Portfolio; Volume: 9; Issue: 1 Linguagem: Inglês

10.1038/s41467-018-07748-z

2041-1723

Juan Camilo Chacón-Duque, Kaustubh Adhikari, Macarena Fuentes‐Guajardo, Javier Mendoza‐Revilla, Víctor Acuña-Alonzo, Rodrigo Barquera, Mirsha Quinto‐Sánchez, Jorge Gómez‐Valdés, Paola Everardo, Hugo Villamil‐Ramírez, Tábita Hünemeier, Virgínia Ramallo, Caio César Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Mercedes Villena, René Vásquez, Elena Llop, José R. Sandoval, Alberto Salazar‐Granara, María Laura Parolín, Karla Sandoval, Rosenda I. Peñaloza‐Espinosa, Héctor Rangel‐Villalobos, Cheryl A. Winkler, William Klitz, Cláudio M. Bravi, Julio Molina, Daniel Corach, Ramiro Barrantes, Verónica Gomes, Carlos Resende, Leonor Gusmão, António Amorim, Yali Xue, Jean‐Michel Dugoujon, Pedro Moral, Rolando González‐José, Lavínia Schüler‐Faccini, Francisco M. Salzano, María Cátira Bortolini, Samuel Canizales‐Quinteros, Giovanni Poletti, Carla Gallo, Gabriel Bedoya, Francisco Rothhammer, David J. Balding, Garrett Hellenthal, Andrés Ruiz‐Linares,

melanin and skin pigmentation

Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.