Produção Nacional
Revisado por pares
Sedative and cardiorespiratory effects of low doses of xylazine with and without acepromazine in Nordestino donkeys
2018; Wiley; Volume: 50; Issue: 6 Linguagem: Inglês
10.1111/evj.12835
ISSN2042-3306
AutoresJ Castillo, Miguel Gozalo‐Marcilla, Mariana Werneck Fonseca, Fábio Sossai Possebon, Ademir Cassiano da Rosa, A. J. A. Aguiar,
Tópico(s)Veterinary Equine Medical Research
ResumoSummary Background Information on appropriate protocols for sedation of Nordestino donkeys is scarce. Objectives To evaluate the sedative and cardiorespiratory effects of low doses of intravenous (i.v.) xylazine with and without acepromazine in ‘Nordestino’ donkeys. Study design Seven healthy female Nordestino donkeys (150 ± 18 kg) were included in this blinded, randomised, crossover experiment. Methods Four treatments were administered, consisting of two i.v. injections, at baseline (T0, 1st injection) and 15 min later (T15, 2nd injection). Treatments included acepromazine 0.05 mg/kg bwt + saline ( AS ), saline + xylazine 0.5 mg/kg bwt ( SX 0.5), acepromazine + xylazine 0.25 mg/kg bwt ( AX 0.25) or acepromazine + xylazine 0.5 mg/kg bwt (AX0.5). Sedative and cardiorespiratory parameters were evaluated before T0 and 15, 20, 30, 45, 60, 75 and 90 min after treatment. Degree [height of head above ground ( HHAG )] and quality of sedation [ataxia, responses to stimuli and visual analogue scale ( VAS ) scoring] and respiratory rate were evaluated by the main investigator in situ, and heart rate was measured by an assistant investigator. Three experienced evaluators assessed vídeos for ataxia and responses to stimuli. Normal data were analysed by repeated measures ANOVA , and non‐normal by Kruskal–Wallis (P<0.05). Results HHAG was lower than baseline for 15 min after xylazine administration in AX 0.25 and for 30 min in SX 0.5 and AX 0.5 groups. All treatments with xylazine increased VAS and ataxia scores in situ for 15 min after xylazine administration, with no differences between groups. Ataxia scores in situ were higher in SX 0.5 and AX 0.5 groups than AS for 15 and 30 min after xylazine administration, respectively. Main limitations Absence of a negative control group (saline‐saline). Conclusion Acepromazine added to xylazine at 0.25 mg/kg bwt produced briefer and milder sedation than xylazine at 0.5 mg/kg bwt.
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