Produção Nacional
Revisado por pares
Early Endoscopic Retrograde Cholangiopancreatography Versus Conservative Treatment in Patients With Acute Biliary Pancreatitis
2018; Lippincott Williams & Wilkins; Volume: 47; Issue: 4 Linguagem: Inglês
10.1097/mpa.0000000000001032
ISSN1536-4828
AutoresLara Meireles de Azeredo Coutinho, Wanderley Marques Bernardo, Rodrigo Silva de Paula Rocha, Fabio R. Marinho, Áureo Delgado, Eduardo T. Moura, Sérgio Matuguma, Dalton Chaves, Tomazo Franzini, Paulo Sakai, Eduardo Guimarães Hourneaux de Moura,
Tópico(s)Pancreatic and Hepatic Oncology Research
ResumoThe aim of the study was to evaluate the role of early endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of acute biliary pancreatitis, in comparison with conservative treatment.Systematic review via databases (MEDLINE [PubMed], Latin-American and Caribbean Health Sciences Literature database, Embase, Cochrane Central, and the [Brazilian] Regional Library of Medicine) is conducted. We analyzed 10 randomized controlled trials (1091 patients). Outcomes were the following: local and systemic adverse events; acute cholangitis; death; length of hospital stay; cost; abdominal pain; and time to a reduction in body temperature. For the meta-analysis, we used risk difference (RD) and mean with standard deviation as measures of variability.There was a statistically significant difference between the patients submitted to ERCP in terms of the following: local adverse events (RD, 0.74; 95% confidence interval [CI], 0.55-0.99), time to pain relief and time to a reduction in axillary temperature (RD, -5.01; 95% CI, -6.98 to -3.04, and RD, -1.70; 95 CI%, -2.33 to -1.08, respectively). Patients undergoing ERCP spent less time in hospital (RD, -11.04; 95% CI, -15.15 to -6.93). Cost was lower in the group treated with ERCP.Early ERCP decreases local adverse events, shortening the time to pain relief, to a reduction in axillary temperature, hospital stays, and cost in patients with acute biliary pancreatitis.
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