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Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study

2018; Wiley; Volume: 62; Issue: 9 Linguagem: Inglês

10.1002/mnfr.201700960

1613-4133

Irene Roncero‐Ramos, Oriol A. Rangel‐Zúñiga, Javier López-Moreno, Juan F. Alcalá‐Díaz, Pablo Pérez‐Martínez, Rosa Jiménez-Lucena, Justo P. Castaño, Helen M. Roche, Javier Delgado‐Lista, José M. Ordovás, Antonio Camargo, José López‐Miranda,

Adipokines, Inflammation, and Metabolic Diseases

Scope Insulin resistance (IR) and chronic low‐grade inflammation are hallmarks of type 2 diabetes mellitus (T2DM). The “NOD‐like receptor pyrin domain containing‐3” (NLRP3) inflammasome component of innate immunity is a metabolic stress sensor modulated by dietary and genetics factors. The aim of this study was to evaluate the effects of the consumption of two diets for 3 years, Mediterranean (Med) and low fat, on glucose homeostasis in the 1002 coronary heart disease patients of the CORDIOPREV study, according to a genetic variant of NLRP3 inflammasome. Methods and results The study was conducted in the framework of the CORDIOPREV study, a randomized dietary intervention with Med and low‐fat diets. Single nucleotide polymorphisms (SNPs) located at inflammasome NLRP3 gene were genotyped by OpenArray platform. Nondiabetic CT+TT carriers of the rs4612666 SNP and AG+AA carriers of the rs10733113 SNP increased insulin sensitivity index (ISI) after 3 years of dietary intervention, whereas no effect was observed in diabetic patients. Further analysis by diet showed that the improvement of the ISI in nondiabetic rs10733113 AG+AA carriers was specific to the consumption of the Med diet. Conclusion Our results show that the benefits associated with a Med diet regarding glucose homeostasis in non‐T2DM patients depend on genetic variation in the inflammasome.