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Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery

2018; Elsevier BV; Volume: 28; Linguagem: Inglês

10.1016/j.ebiom.2018.01.018

2352-3964

Qingrun Li, Ziming Wang, Nicolai J. Wewer Albrechtsen, Dandan Wang, Zhiduan Su, Xianfu Gao, Qingqing Wu, Huiping Zhang, Li Zhu, Rong-Xia Li, SivHesse Jacobsen, Nils B. Jørgensen, Carsten Dirksen, Kirstine N. Bojsen‐Møller, Jacob S. Petersen, Sten Madsbad, Trine R. Clausen, Børge Diderichsen, Luonan Chen, Jens J. Holst, Rong Zeng, Jiarui Wu,

Adipose Tissue and Metabolism

Roux-en-Y Gastric bypass surgery (RYGB) is emerging as a powerful tool for treatment of obesity and may also cause remission of type 2 diabetes. However, the molecular mechanism of RYGB leading to diabetes remission independent of weight loss remains elusive. In this study, we profiled plasma metabolites and proteins of 10 normal glucose-tolerant obese (NO) and 9 diabetic obese (DO) patients before and 1-week, 3-months, 1-year after RYGB. 146 proteins and 128 metabolites from both NO and DO groups at all four stages were selected for further analysis. By analyzing a set of bi-molecular associations among the corresponding network of the subjects with our newly developed computational method, we defined the represented physiological states (called the edge-states that reflect the interactions among the bio-molecules), and the related molecular networks of NO and DO patients, respectively. The principal component analyses (PCA) revealed that the edge states of the post-RYGB NO subjects were significantly different from those of the post-RYGB DO patients. Particularly, the time-dependent changes of the molecular hub-networks differed between DO and NO groups after RYGB. In conclusion, by developing molecular network-based systems signatures, we for the first time reveal that RYGB generates a unique path for diabetes remission independent of weight loss.