Produção Nacional
Revisado por pares
Lymphocyte immunotherapy for recurrent miscarriages: Predictors of therapeutic success
2018; Wiley; Volume: 79; Issue: 6 Linguagem: Inglês
10.1111/aji.12833
ISSN1600-0897
AutoresMarcelo Borges Cavalcante, Manoel Sarno, Marla Niag, Kleber Pimentel, Ivana Luz, Bárbara Figueiredo, Tatiana Michelon, Simone Lima, Isabela Nelly Machado, Edward Araujo Júnior, Ricardo Barini, Jorge Neumann,
Tópico(s)Endometriosis Research and Treatment
ResumoProblem To evaluate the predictors of successful pregnancies in women with a history of recurrent miscarriages ( RM s) having undergone lymphocyte immunotherapy ( LIT ). Method of study Retrospective, multicenter, observational study which involved 702 pregnant women with history of RM treated with LIT . Comparative analysis of women with a history of RM having undergone LIT and experienced treatment success vs those having experienced treatment failure along with the analysis of the association between the number of prior miscarriages and the efficacy of LIT . Results A total of 421 women were able to carry the pregnancy to term, with treatment success rate of 60%. The multivariate analysis showed that age, the association between autoantibodies and thrombophilia, and the number of previous miscarriages were factors associated with LIT failure. Secondary RM s alone were not found to be a factor predictive of LIT success or failure; however, secondary RM s among women with a history of 5 or more RM were found to be a predictor of LIT success ( OR : 10.24; 95% CI : 1.9‐55.8; P = .007). Conclusion Age, the number of previous miscarriages, and the association between autoantibodies and thrombophilia are associated with LIT failure. A higher number of previous miscarriages in cases of secondary RM resulted in better LIT outcomes.
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