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Patient Enrichment for Precision‐Based Cancer Clinical Trials: Using Prospective Cohort Surveillance as an Approach to Improve Clinical Trials

2018; Wiley; Volume: 104; Issue: 1 Linguagem: Inglês

10.1002/cpt.1051

1532-6535

William S. Dalton, Daniel M. Sullivan, Jeffrey Ecsedy, Michael A. Caligiuri,

Genetic factors in colorectal cancer

Technological advances have led to the identification of biomarkers and development of novel target‐based therapies. While some novel therapies have improved patient outcomes, the prevalence and diversity of biomarkers and targets in patient populations, especially patients with cancer, has created a challenge for the design and performance of clinical trials. To address this challenge we propose that prospective cohort surveillance of patients may be a solution to promote clinical trial matching for patients in need.