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Translocation of a gut pathobiont drives autoimmunity in mice and humans

2018; American Association for the Advancement of Science; Volume: 359; Issue: 6380 Linguagem: Inglês

10.1126/science.aar7201

1095-9203

Sílvio M. Vieira, Michael Hiltensperger, Varun Kumar, Daniel F. Zegarra-Ruiz, Carina Dehner, Nafeesa Khan, Frederico R. C. Costa, Eleni Tiniakou, Teri M. Greiling, William Ruff, Andrea Barbieri, Christina Kriegel, Sameet Mehta, James Knight, Dhanpat Jain, Andrew L. Goodman, Martin Kriegel,

Inflammatory Bowel Disease

Bacterial involvement in autoimmunity The composition of the commensal microbiota is known to influence autoimmune disease development and persistence. Manfredo Vieira et al. identified a gut microbe, Enterococcus gallinarum , that translocates from the gut into the organs of mice with a genetic predisposition to lupus-like autoimmunity (see the Perspective by Citi). Molecular signatures of gut barrier disintegration and pathogenic T helper cells were evident in the gut, liver, and lymphoid organs during colonization with the pathobiont. The ensuing pathology could be reversed by vancomycin treatment and by vaccination against E. gallinarum . The same bug was also found in liver biopsies of autoimmune patients, but not in healthy controls. Science , this issue p. 1156 ; see also p. 1097