Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Antifungal activity of Annona coriacea Mart. ethanol extracts against the aetiological agents of cryptococcosis

2018; Taylor & Francis; Volume: 33; Issue: 16 Linguagem: Inglês

10.1080/14786419.2018.1440221

ISSN

1478-6427

Autores

Adriana Araújo de Almeida-Apolonio, Fabiana Gomes da Silva Dantas, Allan Belarmino Rodrigues, Claúdia Andréa Lima Cardoso, Melyssa Negri, Kelly Mari Pires de Oliveira, Marilene Rodrigues Chang,

Tópico(s)

Phytoplasmas and Hemiptera pathogens

Resumo

Cryptococcosis is an opportunistic disease with a worldwide distribution. This disease is caused by fungi of the genus Cryptococcus, and its treatment is limited to several antifungals. In this study, the antifungal, cytotoxic and mutagenic properties of ethanol extracts from the bark and leaves of Annona coriacea were evaluated against the standard Cryptococcus species and clinical yeast specimens. Both extracts of A. coriacea showed inhibitory activity of 1.5 mg/mL for all of the yeasts tested. The number of viable cells at the lowest tested concentration was 0.187 mg/mL. The extracts that were tested showed inhibitory activity and reduced the fungal growth of the Cryptococcus gattii species and Cryptococcus neoformans species complexes, suggesting that this plant may be an effective alternative treatment for cryptococcosis.

Referência(s)