Produção Nacional
Revisado por pares
Hepatoprotective Effect of Essential Oils from Hyptis crenata in Sepsis-Induced Liver Dysfunction
2018; Mary Ann Liebert, Inc.; Volume: 21; Issue: 7 Linguagem: Inglês
10.1089/jmf.2017.0125
ISSN1557-7600
AutoresGlauber Cruz Lima, Yuri Vasconcelos, Marília Trindade de Santana Souza, Alan Santos Oliveira, Rangel Rodrigues Bomfim, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Enilton A. Camargo, Viviane Gomes Portella, Andrelina Noronha Coelho‐de‐Souza, Lúcio Ricardo Leite Diniz,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoNo specific therapeutics are available for the treatment of sepsis-induced liver dysfunction, a clinical complication strongly associated with the high mortality rate of septic patients. This study investigated the effect of the essential oil of Hyptis crenata (EOHc), a lamiaceae plant used to treat liver disturbances in Brazilian folk medicine, on liver function during early sepsis. Sepsis was induced by the cecal ligation and puncture (CLP) model. Rats were divided into four groups: Sham, Sham+EOHc, CLP, and CLP+EOHc. EOHc (300 mg/kg) was orally administered 12 and 24 h after surgery. The animals were sacrificed for blood collection and liver tissue samples 48 h after surgery. Hepatic function was evaluated by measuring serum bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase, and alanine aminotransferase (ALT) levels. The levels of malondialdehyde and the activity of superoxide dismutase, catalase, and GSH peroxidase (GSH-Px) were measured for assessment of oxidative stress. Liver morphology was analyzed by hematoxylin and eosin staining. EOHc normalized serum ALP, ALT, and bilirubin levels and inhibited morphological changes. In addition, we observed that EOHc inhibited elevation in hepatic lipid peroxidation and reduction of the glutathione peroxidase activity induced by sepsis. Our data show that EOHc plays a protective effect against liver injury induced by sepsis.
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