Accelerating Cell Therapy for Stroke in Japan
2018; Lippincott Williams & Wilkins; Volume: 49; Issue: 4 Linguagem: Inglês
10.1161/strokeaha.117.019216
ISSN1524-4628
AutoresKiyohiro Houkin, Hideo Shichinohe, Kōji Abe, Teruyo Arato, Mari Dezawa, Osamu Honmou, Nobutaka Horie, Yasuo Katayama, Kohsuke Kudo, Satoshi Kuroda, Tomohiro Matsuyama, Ichiro Miyai, Izumi Nagata, Kuniyasu Niizuma, Ken Sakushima, Masanori Sasaki, Norihiro Sato, Kenji Sawanobori, Satoshi Suda, Akihiko Taguchi, Teiji Tominaga, Haruko Yamamoto, Toru Yamashita, Toshiki Yoshimine,
Tópico(s)Nerve injury and regeneration
ResumoHomeStrokeVol. 49, No. 4Accelerating Cell Therapy for Stroke in Japan Free AccessReview ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplemental MaterialFree AccessReview ArticlePDF/EPUBAccelerating Cell Therapy for Stroke in JapanRegulatory Framework and Guidelines on Development of Cell-Based Products Kiyohiro Houkin, MD, PhD, Hideo Shichinohe, MD, PhD, Koji Abe, MD, PhD, Teruyo Arato, PhD, Mari Dezawa, MD, PhD, Osamu Honmou, MD, PhD, Nobutaka Horie, MD, PhD, Yasuo Katayama, MD, PhD, Kohsuke Kudo, MD, PhD, Satoshi Kuroda, MD, PhD, Tomohiro Matsuyama, MD, PhD, Ichiro Miyai, MD, PhD, Izumi Nagata, MD, PhD, Kuniyasu Niizuma, MD, PhD, Ken Sakushima, MD, PhD, Masanori Sasaki, MD, PhD, Norihiro Sato, MD, PhD, Kenji Sawanobori, PhD, Satoshi Suda, MD, PhD, Akihiko Taguchi, MD, PhD, Teiji Tominaga, MD, PhD, Haruko Yamamoto, MD, PhD, Toru Yamashita, MD, PhD and Toshiki Yoshimine, MD, PhDon behalf of Working Group for Guidelines on Development of Cell-Based Products for the Treatment of Cerebral Infarction Kiyohiro HoukinKiyohiro Houkin From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Hideo ShichinoheHideo Shichinohe From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Koji AbeKoji Abe From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Teruyo AratoTeruyo Arato From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Mari DezawaMari Dezawa From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Osamu HonmouOsamu Honmou From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Nobutaka HorieNobutaka Horie From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Yasuo KatayamaYasuo Katayama From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Kohsuke KudoKohsuke Kudo From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Satoshi KurodaSatoshi Kuroda From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Tomohiro MatsuyamaTomohiro Matsuyama From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Ichiro MiyaiIchiro Miyai From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Izumi NagataIzumi Nagata From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). , Kuniyasu NiizumaKuniyasu Niizuma From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); D
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