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UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

2018; Springer Nature; Volume: 28; Issue: 3 Linguagem: Inglês

10.1038/cr.2018.16

1748-7838

Andrew Melber, Cole M. Haynes,

Endoplasmic Reticulum Stress and Disease

The mitochondrial network is not only required for the production of energy, essential cofactors and amino acids, but also serves as a signaling hub for innate immune and apoptotic pathways. Multiple mechanisms have evolved to identify and combat mitochondrial dysfunction to maintain the health of the organism. One such pathway is the mitochondrial unfolded protein response (UPR