Portal de Periódicos da CAPES

A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab

2018; SAGE Publishing; Volume: 27; Issue: 7 Linguagem: Inglês

10.1177/0961203318762598

1477-0962

Yurie Satoh, Kazuhisa Nakano, Hiroko Yoshinari, Shingo Nakayamada, S. Iwata, Satoshi Kubo, Ippei Miyagawa, Masahiro Yoshikawa, Yusuke Miyazaki, Kazuyoshi Saito, Yoshiki Tanaka,

Immunodeficiency and Autoimmune Disorders

It has been reported that T helper 17 cells are involved in the pathogenesis of systemic lupus erythematosus, but there is no report on interleukin-17-targeted therapy. We report a case of a 62-year-old female who presented with psoriasis vulgaris and refractory lupus nephritis. Because her conditions were resistant to conventional treatment, and flow cytometry confirmed the proliferation of activated T helper 17 cells in peripheral blood, and examination of a renal biopsy tissue sample confirmed infiltration of numerous interleukin-17-positive lymphocytes to the renal interstitium, administration of the anti-interleukin-17A antibody secukinumab was initiated. After starting secukinumab the clinical and biological features were improved.