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MicroRNA-585 suppresses tumor proliferation and migration in gastric cancer by directly targeting MAPK1

2018; Elsevier BV; Volume: 499; Issue: 1 Linguagem: Inglês

10.1016/j.bbrc.2018.03.116

1090-2104

Lei Hu, Huo Wu, Xiao Wan, Liu Liu, Yi‐Ren He, Liang Zhu, Shaojun Liu, Hanhui Yao, Zhiqiang Zhu,

Cancer-related molecular mechanisms research

Increasing evidence reveals that microRNA contributes to the development and progression of gastric cancer (GC), but the roles of miR-585 in GC remain unclear. In this study, we confirmed that miR-585 was down-regulated in GC tissues and cell lines and that miR-585 expression was related to extent of invasion, TNM stage, lymph node invasion and poor prognosis. Our results showed that miR-585 inhibits the proliferation and migration of GC, and MAPK1 is a direct and functional target of miR-585. Our study sheds light on the role of miR-585 as a suppressor for tumor growth and metastasis and raises the intriguing possibility that miR-585 may serve as a new potential marker for monitoring and treating GC.