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Self-Nanoemulsifying Drug-Delivery Systems Improve Oral Absorption and AntiscHistosomal Activity of Epiisopiloturine

2018; Future Medicine; Volume: 13; Issue: 7 Linguagem: Inglês

10.2217/nnm-2017-0308

1748-6963

Luíza Ianny de Lima, Karen Rapp Py-Daniel, Maria Adelaide Guimarães, Luís Alexandre Muehlmann, Ana Carolina Mafud, Yvonne Primerano Mascarenhas, Josué de Moraes, José Roberto de Souza de Almeida Leite, Cheng‐Shi Jiang, Ricardo Bentes Azevedo, João Paulo Figueiró Longo,

Helminth infection and control

To develop a self-nanoemulsifying drug-delivery system (SNEDDS) able to improve oral absorption of epiisopiloturine (EPI), and test the antischistosomal activity in a mice model.SNEDDS had a nanoscopic size and was able to enhance EPI bioavailability after oral administration, and SNEDDS-EPI (40 mg.kg-1) improved the in vivo antischistosomal activity of EPI, demonstrating that SNEDDS was able to improve the pharmacokinetics of EPI, and to maintain the pharmacodynamic activity against Schistosoma mansoni in vivo.Taken together, these results indicate that SNEDDS-EPI is efficient in reducing worm burden in comparison to treatment with the free version of EPI. [Formula: see text].