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Acute HIV Infection Results in Subclinical Inflammatory Cardiomyopathy

2018; Oxford University Press; Volume: 218; Issue: 3 Linguagem: Inglês

10.1093/infdis/jiy183

1537-6613

Christopher Schuster, Florian Mayer, Corinna Wohlfahrt, Rodrig Marculescu, Michael Skoll, Robert Straßl, Noémi Pávó, Theresia Popow‐Kraupp, Martin Hülsmann, Martin Bauer, Maximilian C. Aichelburg, Armin Rieger, Georg Goliasch,

HIV Research and Treatment

The impact of excess viral RNA on myocardial function and morphology in the setting of acute human immunodeficiency virus (HIV) infection remains unknown. In this study, 49 patients with acute HIV infection showed increased levels of N-terminal prohormone of brain natriuretic peptide, a surrogate of myocardial function, which decreased with viral suppression and normalization of systemic inflammation (79 pg/mL vs 28 pg/mL; P < .001). A comparable change was seen with levels of troponin T, a marker of morphologic myocardial damage (4.9 ng/L vs 1.5 ng/L; P < .001). In conclusion, we observed significant functional and morphological myocardial impairment during acute HIV infection, fueled by inflammatory activation and extensive viral replication, resulting in a reversible subclinical inflammatory cardiomyopathy.