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The Cardiomyopathy Registry of the EURObservational Research Programme of the European Society of Cardiology: baseline data and contemporary management of adult patients with cardiomyopathies

2018; Oxford University Press; Volume: 39; Issue: 20 Linguagem: Inglês

10.1093/eurheartj/ehx819

1522-9645

Philippe Charron, Perry Elliott, Juan R. Gimeno, Alida L.P. Caforio, Juan Pablo Kaski, Luigi Tavazzi, Michał Tendera, Carole Maupain, Cécile Laroche, Paweł Rubiś, Ruxandra Jurcuţ, Leonardo Calò, Tiina Heliö, Gianfranco Sinagra, Marija Zdravković, Aušra Kavoliūnienė, Stephan B. Felix, Jacek Grzybowski, Maria Angela Losi, Folkert W. Asselbergs, José Manuel García‐Pinilla, Joel Salazar‐Mendiguchía, Katarzyna Mizia­‐Stec, Aldo P. Maggioni, Aris Anastasakis, Elena Biagini, Zofia T. Bilińska, Francisco J. Castro, Jelena Čelutkienė, Natalija Chakova, Przemysław Chmielewski, Fabrizio Drago, Attila Frigy, Andrea Frustaci, Pablo García‐Pavía, Saša Hinić, Ingrid Kindermann, Giuseppe Limongelli, Constancio Medrano, Lorenzo Monserrat, Akinsanya Olusegun‐Joseph, Tomás Ripoll‐Vera, Luís R. Lopes, Aly M A Saad, Simone Sala, Petar Seferović, Róbert Sepp, José Ángel Urbano-Moral, Eduardo Villacorta, Maciej Wybraniec, Raquel Yotti, Elisabetta Zachara, Esther Zorio,

Viral Infections and Immunology Research

The Cardiomyopathy Registry of the EURObservational Research Programme is a prospective, observational, and multinational registry of consecutive patients with four cardiomyopathy subtypes: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and restrictive cardiomyopathy (RCM). We report the baseline characteristics and management of adults enrolled in the registry. A total of 3208 patients were enrolled by 69 centres in 18 countries [HCM (n = 1739); DCM (n = 1260); ARVC (n = 143); and RCM (n = 66)]. Differences between cardiomyopathy subtypes (P < 0.001) were observed for age at diagnosis, history of familial disease, history of sustained ventricular arrhythmia, use of magnetic resonance imaging or genetic testing, and implantation of defibrillators. When compared with probands, relatives had a lower age at diagnosis (P < 0.001), but a similar rate of symptoms and defibrillators. When compared with the Long-Term phase, patients of the Pilot phase (enrolled in more expert centres) had a more frequent rate of familial disease (P < 0.001), were more frequently diagnosed with a rare underlying disease (P < 0.001), and more frequently implanted with a defibrillator (P = 0.023). Comparing four geographical areas, patients from Southern Europe had a familial disease more frequently (P < 0.001), were more frequently diagnosed in the context of a family screening (P < 0.001), and more frequently diagnosed with a rare underlying disease (P < 0.001). By providing contemporary observational data on characteristics and management of patients with cardiomyopathies, the registry provides a platform for the evaluation of guideline implementation. Potential gaps with existing recommendations are discussed as well as some suggestions for improvement of health care provision in Europe.