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Fire behind the fury: IL-18 and MAS

2018; Elsevier BV; Volume: 131; Issue: 13 Linguagem: Inglês

10.1182/blood-2018-02-828186

1528-0020

Kenneth L. McClain, Carl E. Allen,

Inflammasome and immune disorders

In this issue of Blood, Weiss et al and Girard-Guyonvarc’h et al demonstrate the ability of free plasma interleukin-18 (IL-18) to distinguish macrophage activation syndrome (MAS) from other inflammatory disorders. Furthermore, with several animal models, they demonstrate that IL-18 is not just a biomarker but rather a driver of inflammation and potential therapeutic target in some patients with MAS. 1,2