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Transcriptional signature associated with early rheumatoid arthritis and healthy individuals at high risk to develop the disease

2018; Public Library of Science; Volume: 13; Issue: 3 Linguagem: Inglês

10.1371/journal.pone.0194205

1932-6203

N. Macías-Segura, Julio Enrique Castañeda‐Delgado, Yadira Bastián, David Santiago‐Algarra, José Dionisio Castillo-Ortiz, A.L. Alemán-Navarro, Elena Jaime-Sánchez, Mariela Gómez-Moreno, C. A. Saucedo-Toral, Edgar E. Lara‐Ramírez, Martín Zapata-Zúñiga, Leonor Enciso‐Moreno, Roberto González‐Amaro, Cesar Ramos‐Remus, José Antonio Enciso‐Moreno,

Galectins and Cancer Biology

Background Little is known regarding the mechanisms underlying the loss of tolerance in the early and preclinical stages of autoimmune diseases. The aim of this work was to identify the transcriptional profile and signaling pathways associated to non-treated early rheumatoid arthritis (RA) and subjects at high risk. Several biomarker candidates for early RA are proposed. Methods Whole blood total RNA was obtained from non-treated early RA patients with 0.92. These genes come from several functional categories associated to inflammation, Wnt signaling and type I interferon pathways. Conclusion The presence of a specific transcriptome in whole blood of RA patients suggests the activation of a specific inflammatory transcriptional signature in early RA development. The set of overexpressed genes in early RA patients that are shared with ACCP+ subjects but not with ACCP- subjects, can represent a transcriptional signature involved with the transition of a preclinical to a clinical RA stage. Some of these particular up-regulated and down-regulated genes are related to inflammatory processes and could be considered as biomarker candidates for disease progression in subjects at risk to develop RA.