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Vitamin D: Emerging Risk Factor for Acute Myocardial Infarction

2018; OMICS Publishing Group; Volume: 04; Issue: 01 Linguagem: Inglês

10.4172/2572-9462.1000125

2572-9462

Palmeira MM, Neves Js, Ribeiro HYU, Neto FOMJ, Rodrigues IS, Pinheiro MCN,

Healthcare Regulation

Introduction: Current scientific evidence suggests a casual association between serum levels 25(OH)-D and an increase in risk for cardiovascular disease (CVD). Vitamin D supplementation establishes significant beneficial effects in reduction of risk factors associated with CVD. Current research also suggests that an increase of 25(OH)- D for at least 30 ng/mL, reduces the risk of CVD. Methods: Between 2012 and 2016, we chose at random 226 patients assisted by the cardiology urgent care of Hospital de Clinicas Gaspar Viana Belem, PA-Brazil with clinical presentation, ECG and enzymes of myocardial necrosis compatible with Acute Coronary Syndrome. The patients were submitted to routines tests, including coronary cineangiography and vitamin D dosage. Results: This sample was composed of 163 men (p<0.0001) and 63 women between 28 and 91 years of age, and the median age was 63.3 years. From the 226 patients under study, 220 (97%, CI 95%: 95.2-99.4) had a degree of coronary blockage above 70% (p<0.0001) and in 158 patients (70%; CI 95%: 63.9-75.9) the blockage was multiarterial (p<0.0001). There was significant association between the degree of obstruction above 70% and multiarterial obstruction (p=0.0214). As for the serum levels of 25-Hydroxy vitamin D, 107 (47%) had adequate levels (greater or equal to 30 ng/mL) and 119 (53%) had hypovitaminosis D, and among these patients, 23 had levels below 20 ng/mL, being considered with important deficiency for this vitamin (p<0.0001). Conclusions: Our study showed high prevalence of low serum concentration of vitamin D in the tropical region of the Brazilian Amazon. Hypovitaminosis D, in particular, levels of vitamin D<30 nmol/L, may be associated with high rates of atherosclerotic blockage and predominance of multiarterial involvement, found in our population sample.